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Mechanistically, -KG decreases Treg differentiation by inhibiting FOXP3 and upregulating inflammatory cytokines such as IFN-, Tbet, and Rorc, suggesting that Th1-type effector T cells are more dependent on glutaminolysis than Treg cells 136

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This led to an increase in the number of macrophages, CD4 + T cells, the proportion of CD4 + T cells, and M1 macrophages as well as inhibition of angiogenesis in the tumor microenvironment [291]

Estimating mortality, morbidity and disability due to malaria among Africas non-pregnant population

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